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2022
ATTCT and ATTCC repeat expansions in the ATXN10 gene affect disease penetrance of spinocerebellar ataxia type 10
C Alejandra Morato Torres, Faria Zafar, Yu-Chih Tsai, Jocelyn Palafox Vazquez, Michael D Gallagher, Ian McLaughlin, Karl Hong, Jill Lai, Joyce Lee, Amanda Chirino-Perez, Angel Omar Romero-Molina, Francisco Torres, Juan Fernandez-Ruiz, Tetsuo Ashizawa, Janet Ziegle, Francisco Javier Jiménez Gil, Birgitt Schüle
Human Genetics and Genomics Advances 2022 Pages 100137
DOI: 10.1016/j.xhgg.2022.100137
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Multiplex imaging of human induced pluripotent stem cell-derived neurons with CO-Detection by indEXing (CODEX) technology
Laurin Heinrich, Faria Zafar, C Alejandra Morato Torres, Jasmine Singh, Anum Khan, Max Yang Chen, Cassandra Hempel, Nadya Nikulina, Jonathan Mulholland, Oliver Braubach, Birgitt Schüle
Journal of Neuroscience Methods 2022 Pages 109653
DOI: 10.1016/j.jneumeth.2022.109653
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Supplement
Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson's disease
Faria Zafar, Vasavi Nallur Srinivasaraghavan, Max Yang Chen, C Alejandra Morato Torres, Birgitt Schüle
Stem Cell Res 2022 Vol. 60 Pages 102733
DOI: 10.1016/j.scr.2022.102733
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Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages
Diba Ahmadi Rastegar, Laura P Hughes, Gayathri Perera, Shikara Keshiya, Siying Zhong, Jianqun Gao, Glenda M Halliday, Birgitt Schüle, Nicolas Dzamko
npj Parkinson's Disease 2022 Vol. 8 Issue 1 Pages 34
DOI: 10.1038/s41531-022-00297-9
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Gene Expression Analysis in Stem Cell-derived Cortical Neuronal Cultures Using Multi-well SYBR Green Quantitative PCR Arrays
V. N. Srinivasaraghavan, F. Zafar and B. Schüle
Bio-protocol 2022 Vol. 12 Issue 1 Pages e4283, DOI: 10.21769/BioProtoc.4283
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Multiplex CRISPR/Cas9-Guided No-Amp Targeted Sequencing Panel for Spinocerebellar Ataxia Repeat Expansions
Y.-C. Tsai, F. Zafar, Z. T. McEachin, I. J. McLaughlin, M. Van Blitterswijk, J. Ziegle, et al.
In: Genomic Structural Variants in Nervous System Disorders, edited by C. Proukakis, Springer US 2022
DOI 10.1007/978-1-0716-2357-2_6, https://doi.org/10.1007/978-1-0716-2357-2_6
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Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum Disorders
Napolioni V, Fredericks CA, Kim Y, Channappa D, Khan RR, Kim LH, Zafar F, Couthouis J, Davidzon GA, Mormino EC, Gitler AD, Montine TJ, Schüle B, Greicius MD.
Biomedicines. 2022 Jan 12;10(1):160. doi: 10.3390/biomedicines10010160.
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2021
The commercial genetic testing landscape for Parkinson's disease
Cook L, Schulze J, Verbrugge J, Beck JC, Marder KS, Saunders-Pullman R, Klein C, Naito A, Alcalay RN; ClinGen Parkinson's Disease Gene Curation Expert Panel and the MDS Task Force for Recommendations for Genetic Testing in Parkinson's Disease; Clinical Genome Resource (ClinGen) Parkinson's Disease Gene Curation Expert Panel Authors; Movement Society Disorder (MDS) Task Force on Recommendations for Clinical Genetic Testing in Parkinson's Disease Authors.
Parkinsonism Relat Disord. 2021 Nov;92:107-111. doi: 10.1016/j.parkreldis.2021.10.001. Epub 2021 Oct 19.
Embryoid Body Formation from Mouse and Human Pluripotent Stem Cells for Transplantation to Study Brain Microenvironment and Cellular Differentiation
Guerra-Crespo M, Collazo-Navarrete O, Ramos-Acevedo R, Morato-Torres CA, Schüle B.
Methods Mol Biol. 2021 Oct 6. doi: 10.1007/7651_2021_433. Online ahead of print.
Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson's disease
Carricarte Naranjo C, Marras C, Visanji NP, Cornforth DJ, Sanchez-Rodriguez L, Schüle B, Goldman SM, Estévez M, Stein PK, Lang AE, Jelinek HF, Machado A.
Clin Auton Res. 2021 Dec;31(6):729-736. doi: 10.1007/s10286-021-00815-4. Epub 2021 Jul 12.
Genomewide Associate Studies of LRRK2 Modifiers of Parkinson's disease
Lai D, Alipanahi B, Fontanillas P, Schwantes-An TH, Aasly J, Alcalay RN, Beecham GW, Berg D, Bressman S, Brice A, Brockman K, Clark L, Cookson M, Das S, Van Deerlin V, Follett J, Farrer MJ, Trinh J, Gasser T, Goldwurm S, Gustavsson E, Klein C, Lang AE, Langston JW, Latourelle J, Lynch T, Marder K, Marras C, Martin ER, McLean CY, Mejia-Santana H, Molho E, Myers RH, Nuytemans K, Ozelius L, Payami H, Raymond D, Rogaeva E, Rogers MP, Ross OA, Samii A, Saunders-Pullman R, Schüle B, Schulte C, Scott WK, Tanner C, Tolosa E, Tomkins JE, Vilas D, Trojanowski JQ; 23andMe Research Team, Uitti R, Vance JM, Visanji NP, Wszolek ZK, Zabetian CP, Mirelman A, Giladi N, Orr Urtreger A, Cannon P, Fiske B, Foroud T.
Ann Neurol. 2021 Jul;90(1):76-88. doi: 10.1002/ana.26094. Epub 2021 May 17.
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Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism
Chittoor-Vinod, V.G.; Nichols, R.J.; Schüle, B.
Int. J. Mol. Sci. 2021, 22, 1045. doi.org/10.3390/ijms22031045
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2020
Loss-of-Function NUBPL Mutation May Link Parkinson's Disease to Recessive Complex I Deficiency
PS Eis, N Huang, JW Langston, E Hatchwell, B Schüle
Front. Neurol., 29 October 2020; doi.org/10.3389/fneur.2020.555961
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The Role of Alpha-Synuclein And Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders.
CAM Torres, Z Wassouf, F Zafar, D Sastre, TF Outeiro, B Schüle.
Int. J. Mol. Sci. 2020, 21(16), 5724; doi.org/10.3390/ijms21165724
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Nonsteroidal Anti-Inflammatory Use and LRRK2 Parkinson's Disease Penetrance.
San Luciano M , Tanner CM, Meng C, Marras C, Goldman SM, Lang AE, Tolosa E, Schüle B, J William Langston JW, Brice A, Corvol J-C, Goldwurm S, Klein C, Brockman S, Berg D, Brockmann K, Ferreira JJ, Tazir M, Mellick GD, Sue CM, Hasegawa K, Tan EK, Bressman S, Saunders-Pullman R, Michael J. Fox Foundation LRRK2 Cohort Consortium
Mov Disord. 2020;10.1002/mds.28189. doi:10.1002/mds.28189
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Pulse-Field capillary electrophoresis of repeat-primed PCR amplicons for analysis of large repeats in Spinocerebellar Ataxia Type 10.
Hashem V, Tiwar A, Bewick B, Teive HAG, Moscovich M, Schüle B, Bushara K, Bower M, McFarland K, Tsai Y-C, Clark T, Tetsuo Ashizawa.
Plos one 15 (3), e0228789. doi.org/10.1371/journal.pone.0228789
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Report of the Phenotype of a Patient with Roberts Syndrome and a Rare ESCO2 Variant
da Costa Almeida CB, Welter AT, Abech GD, Brandão GR, Flores JAM, Schüle B, Francke U, Fiegenbaum M, Zen PRG, Rosa RFM
J Pediatr Genet. 2020 Mar;9(1):58-62. doi: 10.1055/s-0039-1696636.
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Alpha-synuclein physiology and pathology: A perspective on cellular structures and organelles
Bernal-Conde LD, Ramos-Acevedo R, Reyes-Hernández MA, Balbuena-Olvera A, Morales-Moreno ID, Argüero-Sánchez R, Schüle B, Guerra-Crespo M
Frontiers in Neuroscience 13, 1399, 23 January 2020. doi.org/10.3389/fnins.2019.01399.
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2019
Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson’s disease
Carricarte Naranjo C, Marras C, Visanji NP, Cornforth DJ, Sanchez-Rodriguez L, Schüle B, Goldman SM, Estévez M, Stein PK, Lang AE, Jelinek HF, Machado A.
Clin Auton Res. 2019 Dec;29(6):603-614. doi: 10.1007/s10286-019-00632-w.
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Exosome/microvesicle content is altered in leucine‐rich repeat kinase 2 mutant induced pluripotent stem cell‐derived neural cells
Candelario KM, Balaj L, Zheng T, Skog J, Scheffler B, Breakefield X, Schüle B, Steindler DA.
J Comp Neurol. 2019 Nov 19. doi: 10.1002/cne.24819
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LRRK2 modifies alpha-syn pathology and spread in mouse models and human neurons.
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD.
Acta neuropathologica. 2019. doi: 10.1007/s00401-019-01995-0.
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LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients.
Atashrazm F, Hammond D, Perera G, Bolliger MF, Matar E, Halliday GM, Schüle B, Lewis SJG, Nichols RJ, Dzamko N.
Movement disorders : official journal of the Movement Disorder Society. 2019;34(3):406-15. doi: 10.1002/mds.27601.
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2018
A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain
Dhekne HS, Izumi Yanatori I, Gomez RC, Tonelli F, Diez F, Schüle B, Steger M, Alessi DR, Pfeffer SR
eLife 2018;7:e40202 doi: 10.7554/eLife.40202
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Genetic fine-mapping of the Iowan SNCA gene triplication in a patient with Parkinson's disease.
Zafar F, Valappil RA, Kim S, Johansen KK, Chang ALS, Tetrud JW, Eis PS, Hatchwell E, Langston JW, Dickson DW, Schüle B.
NPJ Parkinsons Dis. 2018 Jun 15;4:18. doi: 10.1038/s41531-018-0054-4. eCollection 2018.
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Supplementary Material
Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease.
Piper DA, Sastre D, Schüle B.
Front Neurosci. 2018 Apr 9;12:199. doi: 10.3389/fnins.2018.00199. eCollection 2018. Review.
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LRRK2 p.Ile1371Val Mutation in a Case with Neuropathologically Confirmed Multi-System Atrophy.
Lee K, Nguyen K-D, Sun C, Liu M, Zafar F, Saetern CO, Flierl A, Tetrud JW, Langston JW, Dickson D, Schüle B*. Journal of Parkinson’s disease, 2018, 8 (1), 93-100.
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2017
Clustering of motor and non-motor features in non-parkinsonian relatives of LRRK2 G2019S familial Parkinson’s disease: a multicenter family study.
Mestre TA, Pont-Sunyer C, Visanji N, Ghate T, Kausar F, AlDakheel A, Connolly BS, Gasca-Salas C, Kern DS, Jain J, Slow EJ, Kasten M, Wadia PM, Lim SY, Chuang RS, Zadikoff C, Steeves Tl, Prakash KM, de Bie RM, Thomsen T, A E Lang, Schüle B, Klein C, Tolosa E, Marras C.
Movement Disorders, accepted Nov 15, 2017.
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Derivation of leptomeninges explant cultures from postmortem human brain donors.
Lee, K; Saetern, OC; Nguyen, A; Rodriguez, L; Schüle, B*.
J Vis Exp. 2017 Jan 21;(119).
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Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W.
European journal of neurology. 2017; 24(2):427-e6.
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Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry.
Lee AJ, Wang Y, Alcalay RN, Mejia-Santana H, Saunders-Pullman R, Bressman S, Corvol JC, Brice A, Lesage S, Mangone G, Tolosa E, Pont-Sunyer C, Vilas D, Schüle B, Kausar F, Foroud T, Berg D, Brockmann K, Goldwurm S, Siri C, Asselta R, Ruiz-Martinez J, Mondragón E, Marras C, Ghate T, Giladi N, Mirelman A, Marder K.
Movement Disorders. 2017 Jun 22.
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Heart rate variability in LRRK2-associated Parkinson’s Disease.
Visanji NP, Bhudhikanok GS, Mestre TA, Ghate T, Udupa K, Kowgier M, Kim S, Valappil R, Kausar F, Rogaeva E, Langston JW, Tanner CM, Schüle B, Lang AE, Goldman S, Marras C.
Movement disorders, 2017 Apr;32(4):610-614.
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β2-Adrenoreceptor is a Regulator of the α-Synuclein Gene Driving Risk of Parkinson’s Disease.
Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T and Scherzer CR.
Science. 2017; 357(6354):891-898.
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Parkinson’s disease caused by pure ATXN10 repeat expansion.
Schüle B*, McFarland KN, Lee K, Tsai Y-Ci, Byrne C, Gopi R, Huang N, Langston JW, Clark T, Jiménez Gil FJ, Ashizawa T.
NPJ Parkinson's disease. 2017; 3:27.
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Reversal of mitochondrial DNA damage with LRRK2 kinase inhibition in Parkinson’s disease.
Howlett EH, Jensen N, Belmote F, Zafar F, Hu X, Schüle B, Kaufman BA, Greenamyre JT, Sanders LH.
Human Molecular Genetics, 2017, 26 (22), 4340-4351.
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2016
Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.
Hsieh CH, Shaltouki A, Gonzalez AE, Bettencourt da Cruz A, Burbulla LF, St Lawrence E, Schüle B, Krainc D, Palmer TD, Wang X.
Cell Stem Cell. 2016 Aug 25. pii: S1934-5909(16)30249-1. doi: 10.1016/j.stem.2016.08.002.
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Inflammatory profile in LRRK2-associated prodromal and clinical PD.
Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Gasser T, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W.
J Neuroinflammation. 2016 May 24;13(1):122. doi: 10.1186/s12974-016-0588-5.
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2015
Multisystem Lewy body disease and the other parkinsonian disorders. no
Langston JW, Schüle B, Rees L, Nichols RJ, Barlow C.
Nature Genetics. 2015;47(12):1378–84. doi: doi:10.1038/ng.3454.
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Editorial
Supplementary Material
Comparative genomic hybridization solves a 14-year-old PARKIN mystery.
Schüle B, Hatchwell E, Eis PS, Langston JW.
Annals of Neurology. 2015. doi: 10.1002/ana.24478. PubMed PMID: 26179350.
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Is PARKIN parkinsonism a cancer predisposition syndrome?
Schüle B, Byrne C, Rees L, Langston JW.
Neurology Genetics. 2015;1(4). doi: 10.1212/nxg.0000000000000031.
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Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.
Oliveira LM, Falomir-Lockhart LJ, Botelho MG, Lin KH, Wales P, Koch JC, Gerhardt E, Taschenberger H, Outeiro TF, Lingor P, Schüle B, Arndt-Jovin DJ, Jovin TM.
Cell Death & Disease 2015;6:e1994. doi: 10.1038/cddis.2015.318. PubMed PMID: 26610207.
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2014
Clinical Correlations With Lewy Body Pathology in LRRK2-related Parkinson Disease.
Kalia LV, Lang AE, Hazrati L-N, Fujioka S, Wszolek ZK, Dickson, DW, Ross OA, Van Deerlin VM, Trojanowski JQ, Hurtig H, Alcalay RN, Marder KS, Clark LN, Gaig C, Tolosa E, Ruiz-Martínez J, Marti-Masso JF, Ferrer I, López de Munain A, Goldman SM, Schüle B, Langston JW, Aasly JOGiordana MT, Bonifati V, Puschmann A, Canesi M, Pezzoli G, MauesDePaula A, Hasegawa K, Duyckaerts C, Brice A, Stoessl AJ, Marras C.
JAMA Neurol. doi:10.1001/jamaneurol.2014.2704
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Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
Flierl A, Oliveira LMA, Falomir‑Lockhart LJ, Mak SK, Hesley J, Soldner F, Arndt-Jovin DJ, Jaenisch R, Langston JW, Thomas M. Jovin TM, Schüle B.
PLoS ONE 9(11): e112413. doi:10.1371/journal.pone.0112413
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Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.
Riley BE., Gardai SJ., Emig-Agius D., Bessarabova M., Ivliev AE., Schüle B., Alexander J., Wallace W., Halliday GM., Langston JW., Braxton S., Yednock T., Shaler T., Johnston JA.
PLoS One. 2014 Aug 29;9(8):e102909
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Michael J. Fox Foundation LRRK2 Consortium: geographical differences in returning genetic research data to study participants.
Alcalay RN., Aasly J., Berg D., Bressman S., Brice A., Brockmann K., Chan P., Clark L., Cormier F., Corvol JC., Durr A., Facheris M., Farrer M., Foroud TM., Gasser T., Giladi N., Halter C., Lang A., Langston JW., Marras C., Marti-Masso JF., Ruiz Martinez J., Mejia-Santana H., Mirelman A., Pont-Sunyer C., Orr-Urtreger A., Raymond D., Saunders-Pullman R., Schüle, B., Tanner C., Tolosa E., Urkowitz A., Vilas D., Wise A., Marder K.
Genet Med. 2014 Aug;16(8):644-5
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Gene correction of LRRK2 G2019S mutation reverses mitochondrial DNA damage in iPSC-derived neural cells from Parkinson’s disease patients.
Sanders, L.H., Laganiere, J., Cooper, O., Mak, S.K., Vu, B.J., Huang, A.Y., Paschon, D.E., Vangipuram, M., Sundararajan, R., Urnov F.D., Langston, J.W., Gregory, P.D., Zhang, H.S., Greenamyre, J.T., Isacson, O., Schüle, B.
Neurobiology of Disease, 2014, 62, p.381-6
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2013
DICE, An Efficient System for Iterative Genomic Editing in Human Pluripotent Stem Cells.
Zhu, F; Gamboa, M; Farruggio, AP; Hippenmeyer, S; Tasic, B; Schüle, B; Chen-Tsai, Y; Calos, MP.
Nucleic Acid Research; 2013 Dec 4.
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Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient-derived Neurons.
Chung, CY, Khurana, V, Auluck, PK, Tardiff, DF, Mazzulli, JR, Soldner, F, Baru, V, Lou, Y, Lo, KH, Sahni, N, Yi, S, Freyzon, Y, Cho, S, Mungenast, AE, Muffat, J, Mitalipova, M, Pluth, MD, Jui, NT, Schüle, B., Lippard, SJ, Tsai, LH, Krainc, D, Buchwald, SL, Ting, AY, Jaenisch, R, Lindquist, S.
Science, 24 October 2013 / 10.1126/science.1245296.
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Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease.
Gardai, S.J., Mao, W., Schüle, B., Babcock, M., Schoebel, S., Lorenzana, C., Alexander, J. Glick, H., Hilton, K., Fitzgerald, J.K., Buttini, M., Chiou, S.-S., McConlogue, L., Anderson, J.P., Schenk, D.B., Bard, F., Langston, J.W., Yednock, T., Johnston J.A.
PLoS ONE. 2013; 8(8): e71634. doi:10.1371/journal.pone.0071634.
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Skin Punch Biopsy Explant Culture for Derivation of Primary Human Fibroblasts.
Vangipuram M, Ting D, Kim S, Diaz R, Schüle B.
J Vis Exp. 2013 Jul 7;(77). doi: 10.3791/3779.
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2012
Small Molecules Greatly Improve Conversion of Human-induced Pluripotent Stem Cells to the Neuronal Lineage.
Mak SK, Huang YA, Iranmanesh S, Vangipuram M, Sundararajan R, Nguyen L, Langston JW, Schüle B.
Stem Cells Int. 2012;2012:140427. doi: 10.1155/2012/140427. Epub 2012 Apr 10.
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2011
SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress.
Byers B, Cord B, Nguyen HN, Schüle B, Fenno L, Lee PC, Deisseroth K, Langston JW, Pera RR, Palmer TD.
PLoS One. 2011;6(11):e26159. doi: 10.1371/journal.pone.0026159. Epub 2011 Nov 16.
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Mitochondrial Dysfunction in Skin Fibroblasts from a Parkinson's Disease Patient with an alpha-Synuclein Triplication.
Mak SK, Tewari D, Tetrud JW, Langston JW, Schüle B.
Journal of Parkinson's Disease 1. (2011):175-183. doi: 10.3233/JPD-2011-11025. Epub 2011 Oct 04.
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Call for participation in the neurogenetics consortium within the Human Variome Project.
Haworth A, Bertram L, Carrera P, Elson JL, Braastad CD, Cox DW, Cruts M, den Dunnen JT, Farrer MJ, Fink JK, Hamed SA, Houlden H, Johnson DR, Nuytemans K, Palau F, Rayan DL, Robinson PN, Salas A, Schüle B, Sweeney MG, Woods MO, Amigo J, Cotton RG, Sobrido MJ.
Neurogenetics. 2011 Aug;12(3):169-73. doi: 10.1007/s10048-011-0287-4. Epub 2011 Jun 1.
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Phenotype in Parkinsonian and Nonparkinsonian LRRK2 G2019S Mutation Carriers.
Marras C, Schüle B, Munhoz RP, Rogaeva E, Langston JW, Kasten M, Meaney C, Klein C, Wadia PM, Lim SY, Chuang RS, Zadikof C, Steeves T, Prakash KM, de Bie RM, Adeli G, Thomsen T, Johansen KK, Teive HA, Asante A, Reginold W, Lang AE.
Neurology. 2011 Jul 26;77(4):325-33. doi: 10.1212/WNL.0b013e318227042d. Epub 2011 Jul 13.
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LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress.
Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD, Pera RR.
Cell Stem Cell. 2011 Mar 4;8(3):267-80. PMID: 21362567 [PubMed - in process]
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2009
Can Cellular Models Revolutionize Drug Discovery in Parkinson's Disease?
Schüle B, Pera RA, Langston JW.
Biochim Biophys Acta. 2009 Nov;1792(11):1043-51. Epub 2009 Sep 3. Review. PMID: 19733239 [PubMed - indexed for MEDLINE]
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Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.
Manning-Boğ AB, Schüle B, Langston JW.
Neurotoxicology. 2009 Nov;30(6):1127-32. Epub 2009 Jul 2. PMID: 19576930 [PubMed - indexed for MEDLINE]
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2007
Parkin gene variations and parkinsonism: association does not imply causation.
Langston JW, Tanner CM, Schüle B.
Ann Neurol. 2007 Jan;61(1):4-6. No abstract available. PMID: 17262853 [PubMed - indexed for MEDLINE]
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Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.
Fuchs J, Nilsson C, Kachergus J, Munz M, Larsson EM, Schüle B, Langston JW, Middleton FA, Ross OA, Hulihan M, Gasser T, Farrer MJ.
Neurology. 2007 Mar 20;68(12):916-22. Epub 2007 Jan 24. PMID: 17251522 [PubMed - indexed for MEDLINE]
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Novel features in a patient homozygous for the L347P mutation in the PINK1 gene.
Doostzadeh J, Tetrud JW, Allen-Auerbach M, Langston JW, Schüle B.
Mov Disord. Parkinsonism Relat Disord. 2007 Aug;13(6):359-61. Epub 2006 Oct 19. PMID: 17055324 [PubMed - indexed for MEDLINE]
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